SynRVIS (Synonymous RVIS)¶
Synonymous codon usage has been identified as an important determinant of translational efficiency and mRNA stability in model organisms and human cell lines. However, synonymous variation is largely overlooked as a component of human genetic diversity. We introduced synRVIS (synonymous RVIS), which ranks genes by their constraint against changes in codon optimality. We have illustrated that intolerant synRVIS genes are enriched for disease genes and dosage sensitive genes.